Pathways of sexual desire.

@article{Pfaus2009PathwaysOS,
  title={Pathways of sexual desire.},
  author={James G. Pfaus},
  journal={The journal of sexual medicine},
  year={2009},
  volume={6 6},
  pages={
          1506-1533
        }
}
  • J. Pfaus
  • Published 1 June 2009
  • Biology, Psychology, Medicine
  • The journal of sexual medicine
INTRODUCTION Sexual desire is controlled by brain systems involved in sexual excitation and inhibition. Hypoactive sexual desire disorder (HSDD) may result from hypofunctional excitation, hyperfunctional inhibition, or some mix of the two. AIM This study aimed to identify neurochemical and neuroanatomical systems involved in sexual excitation and inhibition, their role during normal, and hypoactive sexual expressions. METHODS A comprehensive review of the human and animal literature is made… 

Hypoactive Libido: Neurohumoral Characteristics, Regions of the Brain Regulating Sexual Desire, and Its Reactions to Erotic Stimuli

The cited authors conclude that in compliance with their findings severe, rather than mild, HP is an important determinant of HSD, and believe that PRL can produce more positive than negative effects in initiating and maintaining sexual behavior.

The Neurobiology of Sexual Responses and Its Clinical Relevance

The knowledge of the neurobiology of sexuality forms the basis for the treatment of sexual dysfunctions in psychiatry and other areas and is necessary for diagnostics, counseling, and treatment ofSexual problems.

The neurobiology of bremelanotide for the treatment of hypoactive sexual desire disorder in premenopausal women

Animal studies suggest that bremelanotide may affect female sexual desire by activating presynaptic MC4Rs on neurons in the mPOA of the hypothalamus, leading to increased release of DA, an excitatory neurotransmitter that increases sexual desire.

Melanocortin 4 receptor agonism enhances sexual brain processing in women with hypoactive sexual desire disorder

It is suggested that MC4R agonism enhanced sexual brain processing by reducing self-consciousness, increasing sexual imagery, and sensitizing women with HSDD to erotic stimuli.

Bremelanotide for Treatment of Female Hypoactive Sexual Desire

Bremelanotide is a promising way to treat HSDD and showed improvements in desire, arousal, and orgasm scores when 1.75 mg of bremelanotide was administered before sexual activity compared to a placebo.

Physiology of Libido

Libido has always been associated with sexual motivation. The Latin root refers specifically to sexual lust, a term that conjures images of highly motivated behavior. Libido is observed in the

Hypoactive Sexual Desire Disorder

HSDD significantly affects quality of life in women and can effectively be managed by health care providers with appropriate assessments and individualized treatments, according to a concise, clinically relevant, evidence-based review.

Menopause and sexual desire: the role of testosterone

The present short review underlines the role of testosterone (T) in the motivational and satisfaction components of women's sexuality and critically discusses the strategies to treat hypoactive
...

References

SHOWING 1-10 OF 276 REFERENCES

Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist.

It is reported that PT-141, a peptide analogue of alpha-melanocyte-stimulating hormone that binds to central melanocortin receptors, selectively stimulates solicitational behaviors in the female rat, and may be the first identified pharmacological agent with the capability to treat female sexual desire disorders.

What Can Animal Models Tell Us about Human Sexual Response?

Identification of common neurochemical and neuroanatomical substrates of sexual responding between animals and humans suggests that the evolution of sexual behavior has been highly conserved and indicates that animal models of human sexual response can be used successfully as preclinical tools.

Conditioning and Sexual Behavior: A Review

The role of learning in sexual excitement, in behaviors that bring about the opportunity to mate, in courtship and solicitation displays, insexual arousal and copulatory behaviors, in sexual partner preferences, and the short- and long-term influence of copulatory experience on sexual and reproductive function is examined.

Pharmacological and physiological aspects of sexual exhaustion in male rats.

The data suggest that changes in brain androgen receptors account for the inhibition of sexual behavior present during sexual exhaustion and the postejaculatory interval are not mediated by similar mechanisms and that the medial preoptic area does not regulate sexual satiety.

Chronic fluoxetine inhibits sexual behavior in the male rat: reversal with oxytocin

The reversal by Oxytocin of the fluoxetine-induced deficit in ejaculations is consistent with the hypothesis that serotonin suppresses ejaculatory mechanisms by interrupting the action of oxytocin, which normally accompanies sexual behavior.
...