Pathways of microvascular permeability in the synovium of normal and diseased human knees.

@article{Simkin2011PathwaysOM,
  title={Pathways of microvascular permeability in the synovium of normal and diseased human knees.},
  author={Peter A. Simkin and John Earl Bassett},
  journal={The Journal of rheumatology},
  year={2011},
  volume={38 12},
  pages={
          2635-42
        }
}
OBJECTIVE Our study uses the entire proteomes of serum and synovial fluid (SF) to characterize the avenues of microvascular egress of plasma proteins, and quantifies that traffic in normal and diseased human knees. METHODS Paired aliquots of serum and SF were collected from 17 knees of 11 subjects who died without evident joint disease and 16 patients with clinical effusions, fractionated by gel filtration chromatography and analyzed as continuous plots of the SF/serum concentration ratio… CONTINUE READING

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