Pathways of metabolism of [1'-14C]-trans-anethole in the rat and mouse.

  title={Pathways of metabolism of [1'-14C]-trans-anethole in the rat and mouse.},
  author={S V Bounds and John Caldwell},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={24 7},
This study describes the metabolic fate of trans-4'-methoxyprop-[1-14C]enylbenzene, the natural flavor compound trans-anethole, in rats and mice given single doses of 250 mg/kg body weight. In both rats and mice, an essentially quantitative (> 95% of dose) recovery of 14C was obtained with the majority in the 0-24 hr urine. Separation and identification of 18 urinary anethole metabolites were achieved by radio-HPLC, chemical derivatization, and GC/ MS. Anethole undergoes three primary oxidation… CONTINUE READING

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