Pathways of mammalian replication fork restart

  title={Pathways of mammalian replication fork restart},
  author={Eva Petermann and Thomas Helleday},
  journal={Nature Reviews Molecular Cell Biology},
Single-molecule analyses of DNA replication have greatly advanced our understanding of mammalian replication restart. Several proteins that are not part of the core replication machinery promote the efficient restart of replication forks that have been stalled by replication inhibitors, suggesting that bona fide fork restart pathways exist in mammalian cells. Different models of replication fork restart can be envisaged, based on the involvement of DNA helicases, nucleases, homologous… CONTINUE READING
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