Pathways of bradykinin degradation in blood and plasma of normotensive and hypertensive rats.

@article{Dendorfer2001PathwaysOB,
  title={Pathways of bradykinin degradation in blood and plasma of normotensive and hypertensive rats.},
  author={Andreas Dendorfer and Sebastian Wolfrum and M. Wagemann and Fatimunnisa Qadri and Peter Dominiak},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={280 5},
  pages={
          H2182-8
        }
}
Kinins are vasoactive peptide hormones that can confer protection against the development of hypertension. Because their efficacy is greatly influenced by the rate of enzymatic degradation, the activities of various kininases in plasma and blood of spontaneously hypertensive rats (SHR) were compared with those in normotensive Wistar-Kyoto rats (WKY) to identify pathogenic alterations. Either plasma or whole blood was incubated with bradykinin (10 microM). Bradykinin and kinin metabolites were… Expand
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