Pathways of antigen processing.

@article{Blum2013PathwaysOA,
  title={Pathways of antigen processing.},
  author={Janice S Blum and Pamela A. Wearsch and Peter Cresswell},
  journal={Annual review of immunology},
  year={2013},
  volume={31},
  pages={443-73}
}
T cell recognition of antigen-presenting cells depends on their expression of a spectrum of peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) molecules. Conversion of antigens from pathogens or transformed cells into MHC-I- and MHC-II-bound peptides is critical for mounting protective T cell responses, and similar processing of self proteins is necessary to establish and maintain tolerance. Cells use a variety of mechanisms to acquire protein antigens… CONTINUE READING
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