Pathways of DNA double-strand break repair during the mammalian cell cycle.

@article{Rothkamm2003PathwaysOD,
  title={Pathways of DNA double-strand break repair during the mammalian cell cycle.},
  author={Kai Rothkamm and Ines Kr{\"u}ger and Larry H. Thompson and Markus L{\"o}brich},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 16},
  pages={5706-15}
}
Little is known about the quantitative contributions of nonhomologous end joining (NHEJ) and homologous recombination (HR) to DNA double-strand break (DSB) repair in different cell cycle phases after physiologically relevant doses of ionizing radiation. Using immunofluorescence detection of gamma-H2AX nuclear foci as a novel approach for monitoring the repair of DSBs, we show here that NHEJ-defective hamster cells (CHO mutant V3 cells) have strongly reduced repair in all cell cycle phases after… CONTINUE READING
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