Pathways of Ca²⁺ entry and cytoskeletal damage following eccentric contractions in mouse skeletal muscle.

@article{Zhang2012PathwaysOC,
  title={Pathways of Ca²⁺ entry and cytoskeletal damage following eccentric contractions in mouse skeletal muscle.},
  author={Bao-ting Zhang and N. Peter Whitehead and Othon L. Gervasio and Trent F. Reardon and Molly Vale and Diane Fatkin and Alexander Dietrich and Ella W. Yeung and David G. Allen},
  journal={Journal of applied physiology},
  year={2012},
  volume={112 12},
  pages={
          2077-86
        }
}
Muscles that are stretched during contraction (eccentric contractions) show deficits in force production and a variety of structural changes, including loss of antibody staining of cytoskeletal proteins. Extracellular Ca(2+) entry and activation of calpains have been proposed as mechanisms involved in these changes. The present study used isolated mouse extensor digitorum longus (EDL) muscles subjected to 10 eccentric contractions and monitored force production, immunostaining of cytoskeletal… CONTINUE READING
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