Pathways leading to muscle insulin resistance--the muscle--fat connection.

  title={Pathways leading to muscle insulin resistance--the muscle--fat connection.},
  author={Henrike Sell and J{\"u}rgen Eckel and Daniela Dietze-Schroeder},
  journal={Archives of physiology and biochemistry},
  volume={112 2},
Type 2 diabetes is a heterogeneous disease characterized by hyperglycemia and insulin resistance in peripheral tissues such as adipose tissue and skeletal muscle. This review focuses on obesity as one of the major environmental factors contributing to the development of diabetes. It has become evident that adipose tissue represents an active secretory organ capable of releasing a variety of cytokines such as TNFalpha, IL-6, adiponectin and other still unknown factors that might constitute the… CONTINUE READING
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