Pathways in external apical root resorption associated with orthodontia.

  title={Pathways in external apical root resorption associated with orthodontia.},
  author={James Kennedy Hartsfield},
  journal={Orthodontics & craniofacial research},
  volume={12 3},
To review studies investigating if genetic factors play a role in external apical root resorption (EARR) during orthodontic treatment. Heritability estimation in human sib-pairs, comparison of multiple inbred mouse strains, human sib-pair linkage and parents-child trio association studies, and two gene (Il-1b, and P2rx7) knock out mouse models. Heritability for EARR of the maxillary central incisors concurrent with orthodontic treatment is 0.8. DBA/2J, BALB/cJ, and 129P3/J inbred mouse strains… CONTINUE READING

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