Pathways implicated in stem cell migration: the SDF-1/CXCR4 axis.


The hallmark of hematopoietic stem and progenitor cells (HSPCs) is their motility, which is essential for their function, such as recruitment upon demand. Stromal Derived Factor-1 (SDF-1, CXCL12) and its major receptor CXCR4 play major roles in stem cell motility and development. In vitro migration assays, implicating either gradients or cell surface-bound… (More)
DOI: 10.1007/978-1-61779-145-1_19


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