Pathways from weight fluctuations to metabolic diseases: focus on maladaptive thermogenesis during catch-up fat

@article{Dulloo2002PathwaysFW,
  title={Pathways from weight fluctuations to metabolic diseases: focus on maladaptive thermogenesis during catch-up fat},
  author={A G Dulloo and Jean Jacquet and J P Montani},
  journal={International Journal of Obesity},
  year={2002},
  volume={26},
  pages={S46-S57}
}
It has long been known that obesity is a high risk factor for cardiovascular diseases. In more recent years, the analysis of several large epidemiological databases has also revealed that, independently of excess weight, large fluctuations in body weight at some point earlier in life represent an independent risk factor for type 2 diabetes and hypertension—two major contributors to cardiovascular diseases. High cardiovascular morbidity and mortality have indeed been reported in men and women… CONTINUE READING
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