Pathways for the emergence of multi-dideoxynucleoside-resistant HIV-1 variants.

  title={Pathways for the emergence of multi-dideoxynucleoside-resistant HIV-1 variants.},
  author={Shintaro Matsumi and Pope Kosalaraksa and Hsinyi Tsang and Mark F Kavlick and Shigeyoshi Harada and Hiroaki Mitsuya},
  volume={17 8},
OBJECTIVE To investigate the mechanism by which the Q151M mutation in reverse transcriptase (RT) that confers multi-dideoxynucleoside resistance on HIV-1 and that requires a two base change (CAG-->ATG) develops, and to understand the reason for the relatively lengthy period of time required for its emergence under therapy with multiple nucleoside RT inhibitors (NRTI). DESIGN AND METHODS Propagation assays and competitive HIV-1 replication assays were used to evaluate the fitness of various… CONTINUE READING


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