Pathways for the decay of organic dichloramines and liberation of antimicrobial chloramine gases.

@article{Coker2008PathwaysFT,
  title={Pathways for the decay of organic dichloramines and liberation of antimicrobial chloramine gases.},
  author={Melanie Sue Alanda Coker and Wenzhong Hu and S. T. Senthilmohan and Anthony J Kettle},
  journal={Chemical research in toxicology},
  year={2008},
  volume={21 12},
  pages={
          2334-43
        }
}
When neutrophils phagocytose bacteria, they generate the cytotoxic agent hypochlorous acid (HOCl). The specific role that HOCl plays in bacterial killing is unclear. In the phagosome, it should react with neutrophil proteins to form protein chloramines and dichloramines. We investigated the stability of model dichloramines that are likely to be formed on N-terminal amino acids and Lys residues of proteins contained within phagosomes. Dichloramines were much more unstable than their analogous… CONTINUE READING
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