Pathways for mitotic homologous recombination in mammalian cells.

  title={Pathways for mitotic homologous recombination in mammalian cells.},
  author={Thomas Helleday},
  journal={Mutation research},
  volume={532 1-2},
Homologous recombination (HR) is essential for cellular survival in mammals. In this review, the substrates for HR, the pathways of repair, and their end products (i.e. sister chromatid exchange (SCE), gene conversion, deletions or tandem duplications) are discussed. HR is involved in the repair of DNA double-strand breaks (DSBs) and DNA lesions that occur at replication forks. A classical DSB may result in deletions, tandem duplications or gene conversion following two-end recombination repair… CONTINUE READING
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