Pathways Targeted by Antidiabetes Drugs Are Enriched for Multiple Genes Associated With Type 2 Diabetes Risk

@inproceedings{Segr2015PathwaysTB,
  title={Pathways Targeted by Antidiabetes Drugs Are Enriched for Multiple Genes Associated With Type 2 Diabetes Risk},
  author={Ayellet V Segr{\`e} and Nancy J C Wei and David M Altshuler and Jose C Florez},
  booktitle={Diabetes},
  year={2015}
}
Genome-wide association studies (GWAS) have uncovered >65 common variants associated with type 2 diabetes (T2D); however, their relevance for drug development is not yet clear. Of note, the first two T2D-associated loci (PPARG and KCNJ11/ABCC8) encode known targets of antidiabetes medications. We therefore tested whether other genes/pathways targeted by antidiabetes drugs are associated with T2D. We compiled a list of 102 genes in pathways targeted by marketed antidiabetic medications and… CONTINUE READING
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Large - scale genecentric meta - analysis across 39 studies identi fi es type 2 diabetes loci [ published correction appears in

  • R Saxena, CC Elbers, Y Guo
  • Am J Hum Genet
  • 2012

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