Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening.

@article{Abrahams2012PathwayselectiveSO,
  title={Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening.},
  author={Garth L. Abrahams and Anuradha Kumar and Suzana Savvi and Alvin Wei Hung and Shijun Wen and Chris Abell and Clifton E Barry and David R. Sherman and Helena I M Boshoff and Valerie Mizrahi},
  journal={Chemistry & biology},
  year={2012},
  volume={19 7},
  pages={
          844-54
        }
}
Whole-cell screening of Mycobacterium tuberculosis (Mtb) remains a mainstay of drug discovery, but subsequent target elucidation often proves difficult. Conditional mutants that underexpress essential genes have been used to identify compounds with known mechanism of action by target-based whole-cell screening (TB-WCS). Here, the feasibility of TB-WCS in Mtb was assessed by generating mutants that conditionally express pantothenate synthetase (panC), diaminopimelate decarboxylase (lysA), and… CONTINUE READING
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