Pathway identification by network pruning in the metabolic network of Escherichia coli

@article{Gerlee2009PathwayIB,
  title={Pathway identification by network pruning in the metabolic network of Escherichia coli},
  author={Philip Gerlee and L. Lizana and Kim Sneppen},
  journal={Bioinformatics},
  year={2009},
  volume={25 24},
  pages={3282-8}
}
MOTIVATION All metabolic networks contain metabolites, such as ATP and NAD, known as currency metabolites, which take part in many reactions. These are often removed in the study of these networks, but no consensus exists on what actually constitutes a currency metabolite, and it is also unclear how these highly connected nodes contribute to the global structure of the network. RESULTS In this article, we analyse how the Escherichia coli metabolic network responds to pruning in the form of… CONTINUE READING
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