Pathway genetic load allows simultaneous evaluation of multiple genetic associations.

@article{Huebinger2010PathwayGL,
  title={Pathway genetic load allows simultaneous evaluation of multiple genetic associations.},
  author={Ryan M. Huebinger and Harold R. Garner and Robert C Barber},
  journal={Burns : journal of the International Society for Burn Injuries},
  year={2010},
  volume={36 6},
  pages={
          787-92
        }
}
OBJECTIVE Despite the general success of genome-wide association studies, much heritability remains unidentified in many disease states. Some of this 'missing' heritability may lie in epistatic interactions among multiple loci, which are typically ignored. We utilized a method for simultaneous evaluation of epistatic interactions between allelic variations within genes confined to a single pathway, which we have termed as pathway genetic load (PGL). METHODS In separate analyses, we evaluated… CONTINUE READING

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