Pathway for differentiation of human embryonic stem cells to vascular cell components and their potential for vascular regeneration.

@article{Sone2007PathwayFD,
  title={Pathway for differentiation of human embryonic stem cells to vascular cell components and their potential for vascular regeneration.},
  author={Masakatsu Sone and Hiroshi Itoh and Kenichi Yamahara and Jun Yamashita and Takami Yurugi-Kobayashi and Akane Nonoguchi and Yutaka Suzuki and Ting-Hsing Chao and Naoki Sawada and Yasutomo Fukunaga and Kazutoshi Miyashita and Kwijun Park and Naofumi Oyamada and Naoya Sawada and Daisuke Taura and Naohisa Tamura and Yasushi Kondo and Shinji Nito and Hirofumi Suemori and Norio Nakatsuji and Shin-ichi Nishikawa and Kazuwa Nakao},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 10},
  pages={2127-34}
}
OBJECTIVE We demonstrated previously that mouse embryonic stem (ES) cell-derived vascular endothelial growth factor receptor-2 (VEGF-R2)-positive cells can differentiate into both vascular endothelial cells and mural cells. This time, we investigated kinetics of differentiation of human ES cells to vascular cells and examined their potential as a source for vascular regeneration. METHODS AND RESULTS Unlike mouse ES cells, undifferentiated human ES cells already expressed VEGF-R2, but after… CONTINUE READING
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