Pathway choice in glutamate synthesis in Escherichia coli.

  title={Pathway choice in glutamate synthesis in Escherichia coli.},
  author={Robert B. Helling},
  journal={Journal of bacteriology},
  volume={180 17},
Escherichia coli has two primary pathways for glutamate synthesis. The glutamine synthetase-glutamate synthase (GOGAT) pathway is essential for synthesis at low ammonium concentration and for regulation of the glutamine pool. The glutamate dehydrogenase (GDH) pathway is important during glucose-limited growth. It has been hypothesized that GDH is favored when the organism is stressed for energy, because the enzyme does not use ATP as does the GOGAT pathway. The results of competition… CONTINUE READING
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