Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression

@article{Inkster2010PathwaybasedAT,
  title={Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression},
  author={Becky Inkster and Thomas E. Nichols and Philipp G. S{\"a}mann and Dorothee Auer and Florian Holsboer and Pierandrea Muglia and Paul M. Matthews},
  journal={NeuroImage},
  year={2010},
  volume={53},
  pages={908-917}
}
Several lines of evidence implicate glycogen synthase kinase 3 beta (GSK3beta) in mood disorders. We recently reported associations between GSK3beta polymorphisms and brain structural changes in patients with recurrent major depressive disorder (MDD). Here we provide supporting observations by showing that polymorphisms in additional genes encoding proteins directly related to GSK3beta biological functions are associated with similar regional grey matter (GM) volume changes in MDD patients. We… CONTINUE READING
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