Pathway analysis reveals functional convergence of gene expression profiles in breast cancer

@article{Shen2008PathwayAR,
  title={Pathway analysis reveals functional convergence of gene expression profiles in breast cancer},
  author={Ronglai Shen and Arul M. Chinnaiyan and D. Ghosh},
  journal={BMC Medical Genomics},
  year={2008},
  volume={1},
  pages={28 - 28}
}
A recent study has shown high concordance of several breast-cancer gene signatures in predicting disease recurrence despite minimal overlap of the gene lists. It raises the question if there are common themes underlying such prediction concordance that are not apparent on the individual gene-level. We therefore studied the similarity of these gene-signatures on the basis of their functional annotations. We found the signatures did not identify the same set of genes but converged on the… CONTINUE READING

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