Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms.

@article{LaffertyWhyte2009PathwayAO,
  title={Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms.},
  author={Kyle Lafferty-Whyte and Claire J. Cairney and Nigel Balfour Jamieson and Karin A. Oien and William Nicol Keith},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1792 4},
  pages={
          341-52
        }
}
Multiple mechanisms of senescence induction exist including telomere attrition, oxidative stress, oncogene expression and DNA damage signalling. The regulation of the cellular changes required to respond to these stimuli and create the complex senescent cell phenotype has many different mechanisms. MiRNAs present one mechanism by which genes with diverse functions on multiple pathways can be simultaneously regulated. In this study we investigated 12 miRNAs previously identified as senescence… CONTINUE READING

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