Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver

  title={Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver},
  author={Kathrin E Klein and Stefan Winter and Miia Turpeinen and Matthias Schwab and Ulrich M. Zanger},
  booktitle={Front. Pharmacol.},
The human drug metabolizing cytochrome P450 (CYP) 1A2, is one of the major P450 isoforms contributing by about 5-20% to the hepatic P450 pool and catalyzing oxidative biotransformation of up to 10% of clinically relevant drugs including clozapine and caffeine. CYP1A2 activity is interindividually highly variable and although twin studies have suggested a high heritability, underlying genetic factors are still unknown. Here we adopted a pathway-oriented approach using a large human liver bank (n… CONTINUE READING


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