Pathway-Specific Remodeling of Thalamostriatal Synapses in Parkinsonian Mice

@article{Parker2016PathwaySpecificRO,
  title={Pathway-Specific Remodeling of Thalamostriatal Synapses in Parkinsonian Mice},
  author={Philip R.L. Parker and Arnaud L. Lalive and Anatol C Kreitzer},
  journal={Neuron},
  year={2016},
  volume={89},
  pages={734-740}
}
  • Philip R.L. Parker, Arnaud L. Lalive, Anatol C Kreitzer
  • Published in Neuron 2016
  • Biology, Medicine
  • Movement suppression in Parkinson's disease (PD) is thought to arise from increased efficacy of the indirect pathway basal ganglia circuit, relative to the direct pathway. However, the underlying pathophysiological mechanisms remain elusive. To examine whether changes in the strength of synaptic inputs to these circuits contribute to this imbalance, we obtained paired whole-cell recordings from striatal direct- and indirect-pathway medium spiny neurons (dMSNs and iMSNs) and optically stimulated… CONTINUE READING

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