Pathway Signature and Cellular Differentiation in Clear Cell Renal Cell Carcinoma

@inproceedings{Tun2010PathwaySA,
  title={Pathway Signature and Cellular Differentiation in Clear Cell Renal Cell Carcinoma},
  author={Han W Tun and Laura Ann Marlow and Christina A von Roemeling and Simon James Lloyd Cooper and Pamela A. Kreinest and Kevin Xin Chi Wu and Bruce Arthur Luxon and Mala Sinha and Panos Z Anastasiadis and Jacqueline A Copland},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer. The purpose of this study is to define a biological pathway signature and a cellular differentiation program in ccRCC. METHODOLOGY We performed gene expression profiling of early-stage ccRCC and patient-matched normal renal tissue using Affymetrix HG-U133a and HG-U133b GeneChips combined with a comprehensive bioinformatic analyses, including pathway analysis. The results were validated by real time PCR and… CONTINUE READING

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