Pathway-Dependent Effectiveness of Network Algorithms for Gene Prioritization

  title={Pathway-Dependent Effectiveness of Network Algorithms for Gene Prioritization},
  author={Jung Eun Shim and Sohyun Hwang and Insuk Lee and Enrique Hern{\'a}ndez-Lemus},
  booktitle={PloS one},
A network-based approach has proven useful for the identification of novel genes associated with complex phenotypes, including human diseases. Because network-based gene prioritization algorithms are based on propagating information of known phenotype-associated genes through networks, the pathway structure of each phenotype might significantly affect the effectiveness of algorithms. We systematically compared two popular network algorithms with distinct mechanisms--direct neighborhood which… CONTINUE READING
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Network approaches to the genetic dissection of phenotypes in animals and humans

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