Paths from Pesticides to Parkinson's

  title={Paths from Pesticides to Parkinson's},
  author={Freya Kamel},
  pages={722 - 723}
  • F. Kamel
  • Published 16 August 2013
  • Biology
  • Science
High-quality studies of specific chemical pesticides are needed to determine the relationship between exposure and risk of Parkinson's disease. Interest in the relationship between exposure to pesticides and the risk of neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, and Parkinson's disease (PD) is long-standing (1). PD, in particular, has been the subject of much debate in this context (2). Its symptoms typically occur later in life (at age 60 or older… 

PBPK/PD assessment for Parkinson’s disease risk posed by airborne pesticide paraquat exposure

A novel, probabilistic population-based exposure-response approach to quantify the contribution from PQ exposure to prevalence risk of PD and suggests that a mechanistic understanding of the contribution of a specific pesticide exposure to PD risk trends is crucial to enhance insights into the perspective on the impacts of environmental exposure on the neurodegenerative diseases.

Epigenetics Involvement In Parkinson's Disease And Manganese-Induced Neurotoxicity

Study of the molecular mechanisms of the effect of Mn, genetically and epigenetically will be helpful to understand the etiology of PD which is essential for therapeutic strategies of this disease.

Biological functions of selenium and its potential influence on Parkinson's disease.

The aim of this work is to review and discuss studies that have addressed the effects of selenium on Parkinson's disease and to associate the information obtained so that these data and associations serve as input to new research.

microRNAs in Parkinson’s Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches

An overview of the miRNAs recently found to be implicated in PD etiology is provided, with particular focus on their potential relevance as PD biomarkers, as well as their possible use in PD targeted therapy.

Animal Models of Parkinson’s Disease

This chapter discusses the strengths and limitations of mouse, rat, and non-human primate models of Parkinson’s disease and their applications to study the interplay between genetics and environment.

5 Animal Models of Parkinson’s Disease

The strengths and limitations of mouse, rat, and non-human primate models of Parkinson’s disease are discussed and the interplay between genetics and environment and mechanisms underlying Parkinson's disease is untangled.

The emerging role of nutrition in Parkinson's disease

A review of studies that have addressed the role nutrition plays in both neuroprotection and neurodegeneration in Parkinson's disease and describes in detail the nutrients and their putative mechanisms of action in PD.

Occupational exposures and parkinsonism.

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  • Chemistry
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Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson’s Disease

This review will highlight mitochondrial dysfunction as a common pathway involved in both genetic mutations and environmental toxicants linked to PD.



Epidemiology and etiology of Parkinson’s disease: a review of the evidence

Studies that assessed possible shared etiological components between PD and other diseases show that REM sleep behavior disorder and mental illness increase PD risk and that PD patients have lower cancer risk, but methodological concerns exist.

Association between Parkinson’s Disease and Exposure to Pesticides in Southwestern France

The results support the hypothesis of an association between occupational pesticide exposure and PD and point to the need to investigate the role of fungicides, for which toxicological hypotheses exist.

Elevated serum pesticide levels and risk of Parkinson disease.

A significant odds ratio for the presence of beta-HCH in serum to predict a diagnosis of PD vs control and PD vs Alzheimer disease is observed, which provides further evidence for the apparent association between serum beta- HCH and PD.

Rotenone, Paraquat, and Parkinson’s Disease

PD was positively associated with two groups of pesticides defined by mechanisms implicated experimentally—those that impair mitochondrial function and those that increase oxidative stress—supporting a role for these mechanisms in PD pathophysiology.

Pesticides, Microglial NOX2, and Parkinson's Disease

The role of microglia in selective DA neurotoxicity is detailed, what is currently known about the mechanism ofmicroglial NOX2 activation in these key pesticides is highlighted, and the importance for DA neuron survival and PD etiology is described.

Persistent organochlorine pesticides in serum and risk of Parkinson disease

These results provide some support for an increased risk of Parkinson disease with exposure to dieldrin, but chance or exposure correlation with other less persistent pesticides could contribute to the findings.

Exposure to pesticides or solvents and risk of Parkinson disease

The literature supports the hypothesis that exposure to pesticides or solvents is a risk factor for PD, and prospective and high-quality case-control studies are required to substantiate a cause-effect relationship.