Pathotyping isolates of Newcastle disease virus using antipeptide antibodies to pathotype-specific regions of their fusion and hemagglutinin-neuraminidase proteins

@article{Scanlon1999PathotypingIO,
  title={Pathotyping isolates of Newcastle disease virus using antipeptide antibodies to pathotype-specific regions of their fusion and hemagglutinin-neuraminidase proteins},
  author={Denis B Scanlon and Gary L. Corino and Brian J. Shiell and A. J. Della-Porta and Ruth J. Manvell and Dennis J. Alexander and Anthony N. Hodder and Jeffrey John Gorman},
  journal={Archives of Virology},
  year={1999},
  volume={144},
  pages={55-72}
}
Antipeptide antibodies have been evaluated for their abilities to predict the characteristics of the cleavage motifs of the fusion protein precursors (F0) of 25 isolates of Newcastle disease virus (NDV) with a range of virulences, grouped into 12 sets according to their monoclonal antibody reactivities. A Western blot format was used to show that antisera to synthetic peptides representing sequences at the C-termini of the F2-polypeptides of defined pathotypes of NDV usually distinguish between… CONTINUE READING

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