Pathophysiology of water and sodium retention: edematous states with normal kidney function.

@article{Bekheirnia2006PathophysiologyOW,
  title={Pathophysiology of water and sodium retention: edematous states with normal kidney function.},
  author={Mir Reza Bekheirnia and Robert Schrier},
  journal={Current opinion in pharmacology},
  year={2006},
  volume={6 2},
  pages={202-7}
}
Body fluid volume regulation by the kidney relies upon the complex interaction of numerous factors. However, in edematous disorders, extrarenal factors can override the 'innate wisdom' of the kidney. For example, in patients with cardiac failure or liver disease and in pregnant women, the normal kidney continues to retain sodium and water despite expanded blood, plasma and extracellular fluid volumes. Such fluid retention can ultimately lead to pulmonary congestion, ascites or peripheral edema… CONTINUE READING

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