Pathophysiology of vasopressin in edematous disorders.

  title={Pathophysiology of vasopressin in edematous disorders.},
  author={Robert Schrier and Robert L. Howard},
  journal={Nihon Naibunpi Gakkai zasshi},
  volume={65 12},
Sodium and water retention is characteristic of edematous disorders including cardiac failure, cirrhosis, nephrotic syndrome and pregnancy. In recent years the use of a sensitive radioimmunoassay for plasma vasopressin has implicated the role of nonosmotic vasopressin release in the water retention of these edematous disorders. In experimental studies and studies in humans it has been found that the nonosmotic release of vasopressin is consistently associated with activation of the sympathetic… CONTINUE READING