Pathophysiology of upper airway closure during sleep.

  title={Pathophysiology of upper airway closure during sleep.},
  author={Samuel T. Kuna and G Sant'ambrogio},
  volume={266 10},
While the upper airway normally remains patent during quiet breathing in wakefulness and sleep, patients with obstructive sleep apnea have repetitive periods of upper airway closure during sleep. The upper airway closures usually occur at various sites in the pharynx. The patency of the potentially collapsible pharynx during inspiration depends on the balance between subatmospheric pressure in the pharyngeal airway and airway dilating forces generated by pharyngeal muscles. The pressure… CONTINUE READING

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