Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective

  title={Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective},
  author={F. Zaccardi and D. Webb and T. Yates and M. Davies},
  journal={Postgraduate Medical Journal},
  pages={63 - 69}
  • F. Zaccardi, D. Webb, +1 author M. Davies
  • Published 2015
  • Medicine
  • Postgraduate Medical Journal
  • Diabetes mellitus is a complex metabolic disorder associated with an increased risk of microvascular and macrovascular disease; its main clinical characteristic is hyperglycaemia. The last century has been characterised by remarkable advances in our understanding of the mechanisms leading to hyperglycaemia. The central role of insulin in glucose metabolism regulation was clearly demonstrated during the early 1920s, when Banting, Best, Collip and Macleod successfully reduced blood glucose levels… CONTINUE READING
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