Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective

@article{Zaccardi2015PathophysiologyOT,
  title={Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective},
  author={Francesco Zaccardi and David R Webb and Thomas Yates and Melanie Jane Davies},
  journal={Postgraduate Medical Journal},
  year={2015},
  volume={92},
  pages={63 - 69}
}
Diabetes mellitus is a complex metabolic disorder associated with an increased risk of microvascular and macrovascular disease; its main clinical characteristic is hyperglycaemia. The last century has been characterised by remarkable advances in our understanding of the mechanisms leading to hyperglycaemia. The central role of insulin in glucose metabolism regulation was clearly demonstrated during the early 1920s, when Banting, Best, Collip and Macleod successfully reduced blood glucose levels… 
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