Pathophysiology of schizophrenia and the role of newer antipsychotics.

@article{Risch1996PathophysiologyOS,
  title={Pathophysiology of schizophrenia and the role of newer antipsychotics.},
  author={Samuel C. Risch},
  journal={Pharmacotherapy},
  year={1996},
  volume={16 1 Pt 2},
  pages={11-4}
}
Schizophrenia is an illness with numerous neurobiologic features. It is hypothesized that patients may have a relative deficit of dopamine neurotransmission in the nigrostriatal and mesocortical tracts of the brain, as contrasted with an excess of dopamine neurotransmission in the mesolimbic area. The dopamine deficit may be related to the negative symptoms (blunted affect, anhedonia, asociality, inability to initiate and carry out complex tasks to completion) of schizophrenia, whereas the… CONTINUE READING

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