Pathophysiology of rigidity and akinesia in Parkinson's disease.

  title={Pathophysiology of rigidity and akinesia in Parkinson's disease.},
  author={Robert G. L. Lee},
  journal={European neurology},
  volume={29 Suppl 1},
Although rigidity and akinesia are two of the cardinal features of Parkinson's disease, their exact pathophysiology remains uncertain. Mechanisms which may contribute to rigidity include accentuation of the long-latency component of the stretch reflex and enhanced fusimotor drive causing increased sensitivity of muscle spindles. Current evidence concerning the role of these factors in rigidity is reviewed. The relationship between akinesia, prolonged reaction times, and delay in initiation of… CONTINUE READING

From This Paper

Topics from this paper.
24 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…