Pathophysiology of pyoderma gangrenosum (PG): an updated review.

  title={Pathophysiology of pyoderma gangrenosum (PG): an updated review.},
  author={Sara F Braswell and Tassia C Kostopoulos and Alex G Ortega-Loayza},
  journal={Journal of the American Academy of Dermatology},
  volume={73 4},
Pyoderma gangrenosum is a challenging skin condition to identify and treat because of its multifactorial pathogenesis. It is a rare cutaneous manifestation diagnosed clinically by exclusion of infection, neoplasia, thrombophilia, and other inflammatory conditions. Pathogenetic and treatment studies are scarce. Abnormalities in the function of inflammatory cytokines, the immune system, and neutrophils combined with specific genetic mutations predispose patients to develop this complex disease… CONTINUE READING
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