Pathophysiology of preeclampsia: linking placental ischemia/hypoxia with microvascular dysfunction.

@article{Granger2002PathophysiologyOP,
  title={Pathophysiology of preeclampsia: linking placental ischemia/hypoxia with microvascular dysfunction.},
  author={Joey P. Granger and Barbara T. Alexander and Maria Teresa Llin{\'a}s and William A. Bennett and Raouf Ali Khalil},
  journal={Microcirculation},
  year={2002},
  volume={9 3},
  pages={147-60}
}
Studies during the past decade have provided a better understanding of the potential mechanisms responsible for the pathogenesis of preeclampsia. The initiating event in preeclampsia has been postulated to be reduced uteroplacental perfusion as a result of abnormal cytotrophoblast invasion of spiral arterioles. Placental ischemia/hypoxia is thought to lead to widespread activation/dysfunction of the maternal vascular endothelium which results in enhanced formation of endothelin, thromboxane… CONTINUE READING

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