Pathophysiology of myocardial hibernation. Implications for the use of dobutamine echocardiography to identify myocardial viability.

@article{Vanoverschelde1999PathophysiologyOM,
  title={Pathophysiology of myocardial hibernation. Implications for the use of dobutamine echocardiography to identify myocardial viability.},
  author={Jean-Louis Vanoverschelde and Agn{\`e}s Pasquet and Bernhard Gerber and Jacques A. Melin},
  journal={Heart},
  year={1999},
  volume={82 Suppl 3},
  pages={III1-7}
}
Since the pioneering works of Tennant and Wiggers, it has been known that total ischaemia leads to a prompt cessation of contraction and eventually results in the appearance of cell damage and irreversible myocardial necrosis. Accordingly, in the minds of many cardiologists, the discovery of an abnormal regional contraction in a patient with coronary artery disease had long been equated with the presence of irreversible myocardial necrosis. However, with the advent of recanalisation treatment… CONTINUE READING