Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock

@inproceedings{Backer2014PathophysiologyOM,
  title={Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock},
  author={Daniel De Backer and Diego Orbegozo Cort{\'e}s and Katia Donadello and Josef Krascal Vincent},
  booktitle={Virulence},
  year={2014}
}
Multiple experimental and human trials have shown that microcirculatory alterations are frequent in sepsis. In this review, we discuss the various mechanisms that are potentially involved in their development and the implications of these alterations. Endothelial dysfunction, impaired inter-cell communication, altered glycocalyx, adhesion and rolling of white blood cells and platelets, and altered red blood cell deformability are the main mechanisms involved in the development of these… CONTINUE READING

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