Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock

Abstract

Multiple experimental and human trials have shown that microcirculatory alterations are frequent in sepsis. In this review, we discuss the various mechanisms that are potentially involved in their development and the implications of these alterations. Endothelial dysfunction, impaired inter-cell communication, altered glycocalyx, adhesion and rolling of… (More)
DOI: 10.4161/viru.26482

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