Pathophysiology of levodopa-induced dyskinesias in Parkinson's disease: problems with the current model.

@article{Obeso2000PathophysiologyOL,
  title={Pathophysiology of levodopa-induced dyskinesias in Parkinson's disease: problems with the current model.},
  author={Jose A. Obeso and Maria C. Rodriguez-Oroz and Manuel T Rodriguez and Mahlon R. Delong and Charles W. Olanow},
  journal={Annals of neurology},
  year={2000},
  volume={47 4 Suppl 1},
  pages={S22-32; discussion S32-4}
}
The anatomical and physiological basis of levodopa-induced dyskinesias (LIDs) in patients with Parkinson's disease (PD) is reviewed in the light of the current model for the organization of the basal ganglia. This model, which was developed in the late 1980s, works relatively well in explaining the motor features of PD but, for example, it does not account for why tremor, rigidity, bradykinesia, gait dysfunction and postural instability present to differing degrees in different patients, and… CONTINUE READING