Pathophysiology of hypercortisolism in depression.

@article{Carroll2007PathophysiologyOH,
  title={Pathophysiology of hypercortisolism in depression.},
  author={Bernard J. Carroll and Frederick Cassidy and David F. Naftolowitz and Nicola Tatham and William Harwell Wilson and Ali Iranmanesh and Peter Y Liu and Johannes D. Veldhuis},
  journal={Acta psychiatrica Scandinavica. Supplementum},
  year={2007},
  volume={433},
  pages={
          90-103
        }
}
OBJECTIVE The mechanisms mediating hypercortisolemia in depression remain controversial. Adopting the biomarker strategy, we studied adrenocorticotropin (ACTH) and cortisol dynamics in hypercortisolemic and non-hypercortisolemic depressed in-patients, and in normal volunteers. METHOD Deconvolution analysis of 24-h pulsatile secretion, approximate entropy (ApEn) estimation of secretory regularity, cross-ApEn quantitation of forward and reverse ACTH-cortisol synchrony, and cosine regression of… CONTINUE READING
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