Pathophysiology of human visceral obesity: an update.

@article{Tchernof2013PathophysiologyOH,
  title={Pathophysiology of human visceral obesity: an update.},
  author={Andr{\'e} Tchernof and Jean-Pierre Despr{\'e}s},
  journal={Physiological reviews},
  year={2013},
  volume={93 1},
  pages={
          359-404
        }
}
Excess intra-abdominal adipose tissue accumulation, often termed visceral obesity, is part of a phenotype including dysfunctional subcutaneous adipose tissue expansion and ectopic triglyceride storage closely related to clustering cardiometabolic risk factors. Hypertriglyceridemia; increased free fatty acid availability; adipose tissue release of proinflammatory cytokines; liver insulin resistance and inflammation; increased liver VLDL synthesis and secretion; reduced clearance of triglyceride… 

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References

SHOWING 1-10 OF 679 REFERENCES
Role of body fat distribution and the metabolic complications of obesity.
  • M. Jensen
  • Medicine
    The Journal of clinical endocrinology and metabolism
  • 2008
TLDR
Lower body, upper body sc, and visceral fat depots have unique characteristics with regards to fatty acid metabolism, and Selective dysregulation of these depots probably plays an important role with the metabolic complications of obesity.
The regulation of adipose tissue distribution in humans.
  • P. Björntorp
  • Medicine, Biology
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
  • 1996
TLDR
Results of studies in vitro indicate that this difference is diminished at the menopause, and restored by estrogen substitution, suggesting that the functional effects of estrogens in women are similar to those of T in men, and fits well with physiological, and clinical conditions with increased visceral fat mass.
Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity
TLDR
In morbidly obese women region-specific variations in mean adipocyte size are associated with metabolic complications but not systemic or adipose inflammation, and hyperplasia in both adipose regions may be protective against lipid as well as glucose/insulin abnormalities in obesity.
Signalling role of adipose tissue: adipokines and inflammation in obesity.
TLDR
The elevated production of inflammation-related adipokines is increasingly considered to be important in the development of diseases linked to obesity, particularly Type II diabetes and the metabolic syndrome.
Estrogens and glucocorticoid hormones in adipose tissue metabolism.
TLDR
The interaction between glucocorticoids and sex steroids and their influence on adipocyte metabolism is summarized and discussed.
Adipocytokines and the metabolic complications of obesity.
  • N. Rasouli, P. Kern
  • Biology, Medicine
    The Journal of clinical endocrinology and metabolism
  • 2008
TLDR
Inflamed fat in obesity secretes an array of proteins implicated in the impairment of insulin signaling, and the characteristics of different adipocytokines, including leptin, adiponectin, pro-inflammatory cytokines, resistin, retinol binding protein 4, visfatin, and others, and their roles in the pathogenesis of insulin resistance are analyzed.
Hypertrophy and hyperplasia of abdominal adipose tissues in women
TLDR
These results show that in obese women, hyperplasia is predominant in the subcutaneous fat depot, whereas fat cell hypertrophy is observed both in the omental and sub cutaneous compartments.
In vitro lipid synthesis in human adipose tissue from three abdominal sites.
TLDR
Investigation of cellular mechanisms that might contribute to enlargement of intra-abdominal adipocytes, lipolysis, triacylglycerol (TG), and diacyl Glyceride (DG) synthesis from [14C]glucose was measured in abdominal subcutaneous, omental, and mesenteric adipose tissue from severely obese women and men.
Visceral Adipocyte Hypertrophy is Associated With Dyslipidemia Independent of Body Composition and Fat Distribution in Women
TLDR
It is suggested that omental, but not subcutaneous, adipocyte hypertrophy is associated with an altered lipid profile independent of body composition and fat distribution in women.
Human Mesenteric Adipose Tissue Plays Unique Role Versus Subcutaneous and Omental Fat in Obesity Related Diabetes
TLDR
The obesity-related gene expressions in the mesenteric adipose tissue are up regulated, suggesting that the alterations of these genes in mesentery adipose depot may play a critical role in insulin resistance of type 2 diabetes and metabolic syndrome.
...
1
2
3
4
5
...