Pathophysiology of genetic deficiency in tissue kallikrein activity in mouse and man.

@article{Waeckel2013PathophysiologyOG,
  title={Pathophysiology of genetic deficiency in tissue kallikrein activity in mouse and man.},
  author={Ludovic Waeckel and Louis Potier and Christine Richer and Ronan Roussel and N Bouby and François Alhenc-G{\'e}las},
  journal={Thrombosis and haemostasis},
  year={2013},
  volume={110 3},
  pages={
          476-83
        }
}
Study of mice rendered deficient in tissue kallikrein (TK) by gene inactivation and human subjects partially deficient in TK activity as consequence of an active site mutation has allowed recognising the physiological role of TK and its peptide products kinins in arterial function and in vasodilatation, in both species. TK appears as the major kinin forming enzyme in arteries, heart and kidney. Non-kinin mediated actions of TK may occur in epithelial cells in the renal tubule. In basal… CONTINUE READING

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