Pathophysiology of gastroesophageal reflux disease.

@article{Orlando2008PathophysiologyOG,
  title={Pathophysiology of gastroesophageal reflux disease.},
  author={Roy Charles Orlando},
  journal={Journal of clinical gastroenterology},
  year={2008},
  volume={42 5},
  pages={584-8}
}
The pathophysiology of gastroesophageal reflux disease remains incompletely understood. Its hallmark symptom is "heartburn" and, on the basis of endoscopy, those with heartburn are subdivided into nonerosive reflux disease and erosive esophagitis. Although subjects with nonerosive reflux disease have no gross damage on endoscopy, a characteristic histopathologic feature of this disease is present on endoscopic biopsy. This lesion is known as "dilated intercellular spaces," a finding present… CONTINUE READING

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