Pathophysiology of dystonia.

  title={Pathophysiology of dystonia.},
  author={Mark Hallett},
  journal={Journal of neural transmission. Supplementum},
  • Mark Hallett
  • Published 2006 in Journal of neural transmission. Supplementum
Understanding of the pathophysiology of dystonia derives primarily from studies of focal dystonias. Physiological investigations have revealed a number of abnormalities that may reflect the genetic substrate that predisposes certain individuals to develop dystonia. There is a loss of inhibition in the central nervous system, and a loss of surround inhibition specifically. Plasticity is increased, and there are sensory abnormalities. Which of these disorders is primary is uncertain.