Pathophysiology of contrast-induced nephropathy.

@article{Wong2012PathophysiologyOC,
  title={Pathophysiology of contrast-induced nephropathy.},
  author={P. Wong and Z. Li and J. Guo and A. Zhang},
  journal={International journal of cardiology},
  year={2012},
  volume={158 2},
  pages={
          186-92
        }
}
Contrast media induce various factors that may increase vasoconstriction and decrease vasodilatation in the renal medulla, leading to hypoxia and acute tubular necrosis known as contrast-induced nephropathy (CIN) that tends to occur in diabetics and patients with preexisting renal insufficiency. Contrast media inhibit mitochondrial enzyme activities and subsequently increase adenosine through hydrolysis of ATP. Both catabolism of adenosine and medullary hypoxia generate reactive oxygen species… Expand

Paper Mentions

Sildenafil prevents renal dysfunction in contrast media-induced nephropathy in Wistar rats
Molecular Mechanisms of Renal Cellular Nephrotoxicity due to Radiocontrast Media
Microvascular resistance in response to iodinated contrast media in normal and functionally impaired kidneys
Pharmacological Strategies to Prevent Contrast-Induced Acute Kidney Injury
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References

SHOWING 1-10 OF 68 REFERENCES
Contrast media-induced nephrotoxicity--questions and answers.
  • S. Morcos
  • Medicine
  • The British journal of radiology
  • 1998
Regional alterations in renal haemodynamics and oxygenation: a role in contrast medium-induced nephropathy.
  • S. Heyman, C. Rosenberger, S. Rosen
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2005
Role of oxidative stress in contrast-induced acute kidney injury in diabetes mellitus.
...
1
2
3
4
5
...