Pathophysiology of clinical benign prostatic hyperplasia.

  title={Pathophysiology of clinical benign prostatic hyperplasia.},
  author={Ellen Shapiro and Herbert Lepor},
  journal={The Urologic clinics of North America},
  volume={22 2},
The pathophysiology of clinical BPH has been attributed to bladder outlet obstruction resulting from the enlarged prostate. A direct relationship does not exist between prostate size, symptom severity, or bladder outlet obstruction. The pathophysiology of prostatism is most likely multifactorial. Elucidating the factors contributing to symptoms will likely provide the foundation for the development of new pharmacological alternatives for the medical treatment of BPH.