Pathophysiology of cerebellar dysfunction in the Wernicke-Korsakoff syndrome.

  title={Pathophysiology of cerebellar dysfunction in the Wernicke-Korsakoff syndrome.},
  author={Roger F. Butterworth},
  journal={The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques},
  volume={20 Suppl 3},
Cerebellar ataxia is a common presenting sign in the Wernicke-Korsakoff syndrome (WKS). Recovery from ataxia following thiamine treatment is rarely complete, suggesting the existence of both a reversible ("biochemical") lesion as well as irreversible, neuropathological damage. Cerebellar pathology in WKS includes severe loss of Purkinje cells in superior cerebellar vermis as well as neuronal loss from the granular layer. In addition, damage to inferior olivary nucleus could result in loss of… CONTINUE READING