Pathophysiology of cerebellar ataxia
@article{Diener1992PathophysiologyOC, title={Pathophysiology of cerebellar ataxia}, author={H. C. Diener and Johannes Dichgans}, journal={Movement Disorders}, year={1992}, volume={7} }
Human and animal experiments performed recently have resulted in a more detailed understanding of limb movement and body posture disorders associated with cerebellar dysfunction. The delay in movement initiation can be explained by a delay in onset of phasic motor cortex neural discharge owing to decreased input from the cerebellar hemispheres. Disorders of movement termination (dysmetria), which can occur for movements at proximal and distal joints, result from disturbances of the timing and…
245 Citations
Cerebellar Control of Movement
- Psychology, Biology
It is generally agreed that defective motor coordination is a principal feature of diseases of the cerebellum and that the disturbances of coordinated movements are manifested by lack of smoothness during movement execution, and that patients with cerebellar disorders show multiple peaks in the velocity profiles of movements.
Coordination of multi-joint arm movements in cerebellar ataxia:
Analysis of hand and angular kinematics
- BiologyExperimental Brain Research
- 1998
It is suggested that kinematic movement abnormalities that characterize cerebellar limb ataxia are related to an impairment in scaling movement variables such as joint acceleration and deceleration normally with movement speed.
Cerebellar motor syndrome from children to the elderly.
- Psychology, BiologyHandbook of clinical neurology
- 2018
Quantitative evaluation of cerebellar ataxia based on pathological patterns of the muscle activities
- Psychology, Biology2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
- 2013
Two parameters from the EMG signals of the four wrist prime movers are extracted, which characterize the pathological patterns of muscle activities for the cerebellar ataxia, Total Co-contraction Level (TCL) and Directionality of Muscle Activity (DMA).
Postural dysfunction in a transgenic mouse model of spinocerebellar ataxia type 3
- Biology, PsychologyNeuroscience
- 2013
Disturbances of antagonistic neck innervation in patients with cerebellar deficits
- Medicine, BiologyJournal of the Neurological Sciences
- 1998
Reversible block of cerebellar outflow reveals cortical circuitry for motor coordination
- Psychology, BiologybioRxiv
- 2018
Results indicate that the timing of actions, but not the selection of muscles, is regulated through cerebellar control of motor cortical activity, which organizes execution-related activity of a motor cortical subnetwork.
Cerebellar ataxia and muscle spindle sensitivity.
- Biology, PsychologyJournal of neurophysiology
- 1993
It is concluded that the cerebellar nuclei studied are not primarily responsible for fusimotor control, nor is the ataxia primarily caused by disordered proprioceptive sensitivity.
A New Method for Functional Evaluation of Motor Commands in Patients with Cerebellar Ataxia
- Biology, PsychologyPloS one
- 2015
The present results indicate that this ability to accommodate motor commands to the task requirements provides a novel quantitative parameter to characterize motor functions in patients with cerebellar ataxia.
The Relevance of Sensory Input for the Cerebellar Control of Movements
- Biology, PsychologyNeuroImage
- 1997
The results indicate that the neocerebellum may be much more concerned with sensory information processing than has been considered previously.
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