Pathophysiology of cerebellar ataxia

@article{Diener1992PathophysiologyOC,
  title={Pathophysiology of cerebellar ataxia},
  author={H. C. Diener and Johannes Dichgans},
  journal={Movement Disorders},
  year={1992},
  volume={7}
}
Human and animal experiments performed recently have resulted in a more detailed understanding of limb movement and body posture disorders associated with cerebellar dysfunction. The delay in movement initiation can be explained by a delay in onset of phasic motor cortex neural discharge owing to decreased input from the cerebellar hemispheres. Disorders of movement termination (dysmetria), which can occur for movements at proximal and distal joints, result from disturbances of the timing and… 
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References

SHOWING 1-10 OF 59 REFERENCES
Changes in motor cortex neural discharge associated with the development of cerebellar limb ataxia.
TLDR
A variety of disorders, i.e., in the generation of central commands that initiate movements and in the regulation of the gain and phase of proprioceptive feedback, contribute to the development of limb ataxia during cerebellar dysfunction.
Movement and electromyographic disorders associated with cerebellar dysmetria.
TLDR
It is concluded that normal function of the cerebellum is necessary for the generation of agonist and antagonist muscle activity that is both of the appropriate magnitude and timing to control the dynamic phase of arm movements.
Disturbances in human arm movement trajectory due to mild cerebellar dysfunction.
TLDR
It is demonstrated that, despite little or no obvious impairment of the limb during routine examination, the temporal structure of voluntary movements in cerebellar patients is clearly disturbed, which supports the view that the production of an optimal movement trajectory is under Cerebellar influence.
Evidence that a disordered servo-like mechanism contributes to tremor in movements during cerebellar dysfunction.
TLDR
It is suggested that discontinuities and tremor in movements during cerebellar dysfunction result from the same mechanism: alternation between disordered stretch reflexes and disordered servo-assistance mechanisms, both partly involving transcortical pathways.
Pattern of recovery following cerebellar deep nuclear lesions in monkeys.
TLDR
Analysis of data suggests that the cerebellum provides a timing device for movement which matches limb fixation with phasic movement so that the limb fixation stops at the right moment for thephasic component to begin.
Coordination of a multi-joint movement in normal humans and in patients with cerebellar dysfunction.
  • W. Becker, E. Kunesch, H. Freund
  • Psychology, Medicine
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
  • 1990
TLDR
Patients with cerebellar cortical atrophy showed abnormalities in visual-motor coordination, in that they were unable to consistently produce the appropriate hand direction in response to a visual target.
Quantitative analysis of stance in late cortical cerebellar atrophy of the anterior lobe and other forms of cerebellar ataxia.
TLDR
Tremor and characteristically exaggerated intersegmental responses between head, trunk, hips and legs are interpreted as the consequence of hyper-excitability of postural reflexes in patients with cerebellar lesions.
Cerebellar dysmetria at the elbow, wrist, and fingers.
TLDR
Cerebellar patients with dysmetria showed hypermetria followed by tremor at all three joints when movements were made with the manipulanda, and an asymmetry with decreased peak accelerations and increased peak decelerations compared to normal movements could be used clinically as sensitive indicators of cerebellar dysfunction.
Delayed and enhanced long latency reflexes as the possible cause of postural tremor in late cerebellar atrophy.
TLDR
Postural tremor can be synchronized by a single bilateral electrical stimulus and can even be elicited in incipient cases of the disease.
Characteristic alterations of long-loop "reflexes" in patients with Friedreich's disease and late atrophy of the cerebellar anterior lobe.
TLDR
The most specific finding in all of the patients suffering from Friedreich's ataxia (affecting spinal afferents) was the massive delay of the stabilising response of the anterior tibial muscle.
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